Toxicology & Applied Science

Toxicology & Applied Science

Regulatory framework for identification and characterization of endocrine disrupters

For decades, studies of endocrine disrupters (EDs) have challenged traditional concepts in toxicology, in particular the dogma “the dose makes the poison” as they can have effects at low doses that are not predicted by effects at higher doses. At the beginning of the 90s the term endocrine disruption first appeared in scientific literature and a workshop […]

Potential of alkyl glycol ethers to cause endocrine disruption

An endocrine disruptor is defined as “an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations” (WHO/PCS, 2002). In recent years publications have appeared that mention individual glycol ethers or glycol ethers in general amongst those substances with […]